Oncotype DX® Breast Recurrence Score
49 Year-Old Female Patient
with 7 cm 2
CASE SUBMITTED BY:
Czech Republic

Patient Details

MENOPAUSAL STATUS:
Pre-Menopausal
TUMOR TYPE:
Lobular
TUMOR SIZE:
7 cm
ER STATUS (IHC):
Not Provided
PR STATUS (IHC):
Not Provided
HER2/NEU STATUS:
IHC 2+ & ISH- (negative)
Ki-67 STATUS:
Not Available
HISTOLOGIC GRADE:
2
LYMPH NODE STATUS:
Negative
GENERAL HEALTH:
PS0WHO, no comorbidities
RECURRENCE SCORE RESULT:
9
TREATMENT GIVEN:
Tamoxifen
Oncotype DX® Patient Report

Exploratory Subgroup Analysis for TAILORx and NSABP B-20 indicate that Recurrence Score® and age are the strongest predictors of chemotherapy benefit1. The absolute reduction of distant recurrence from chemotherapy for patients >50 years and ≤50 years is shown here for RS groups: 11-15, 16-20, and 21-25 from TAILORx, and 0-10 and 26-100 from NSABP B-202.

Estimated Chemotherapy Benefit for Individual Recurrence Score Results

Recurrence Score ranges shown reflect randomized patients in NSABP B-20 and TAILORx.

References

1. Sparano et al. N Engl J Med. 2018.; ECOG and Genomic Health (data on file).
2. Paik et al. J Clin Oncol. 2006.; Sparano and Paik J Clin Oncol. 2008.

Disclaimer: These case studies are brought to you for educational purposes only and should not be interpreted as an endorsement of Exact Sciences or its services by the submitting physician. The information reflects the interpretive diagnostic opinions of the treating physicians and is not intended to represent a standard of care. The case studies describe real-life cases of patients who have been prescribed the Oncotype DX® test. They are not necessarily representative of all tested patients, and the result in any given case will vary. The examples are not necessarily representative of all of those who will use our clinical tests. Exact Sciences does not endorse any of the contributors featured on this site and takes no view as to the treatment decisions reported in these cases.

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Age
49
NODE Negative
Size
7 cm
Grade
2

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