Prostate Cancer - Early Stage

Interpreting Your Oncotype DX Genomic Prostate Score Results

Each case of prostate cancer is unique. It’s important for you and your doctor to explore the management option that addresses your situation and can most effectively manage your health. The results from the Oncotype DX Genomic Prostate Score (GPS Report) can help you and your doctor better understand the likelihood of aggressive disease, which can help make decisions about how to treat your cancer.

When you will get the results

It usually takes up to two weeks from the time the biopsy is received in lab for the results to be available to your doctor.

The Oncotype DX GPS report is sent to your doctor and the pathologist who submitted your tissue sample. Once they receive the report, they will contact you to discuss the results.

Has your doctor ordered the test?

 

Has Your Doctor Ordered Oncotype DX for you?

Watch this video to understand how Oncotype DX can help with your cancer treatment decision.

 

Understanding your score

 

What can you learn from your test results?

Watch this video to prepare for your Oncotype DX test results and discuss next steps with your doctor.

 


GPS Result

The GPS Result is a score between 0 and 100 that measures the activity (expression) of certain genes within the tumor. In the example above, the patient has a GPS score of 15, consistent with very-low-risk cancer, according to NCCN Guidelines (National Comprehensive Cancer Network).

Genomic Prostate Score Result


Your Individualized Level of Risk

Your report will also include clinical endpoints that further define your individual risk.

  • Prostate cancer death: In the sample report above, the risk of prostate cancer death within 10 years is <1%.
  • Metastasis: The risk of metastasis (cancer spreading beyond the prostate) within 10 years after surgery is shown in this example to be 1%.
  • Adverse pathology: The risk of aggressive disease is shown in this example as 18%. Since this risk is low, the disease will probably not progress quickly.

Individual Risk Prostate Cancer


How to use the results

Once you have the results, you and your doctor can use GPS to aid discussions about your treatment options and help you make the best decision for you personally. Treatment plans often consider things like:

  • Your doctor’s assessment of your overall cancer risk, taking into account biopsy, PSA, GPS, etc.
  • Your age, overall health, and lifestyle.

Doctor Patient Discussion

For example, the higher your GPS, the more likely it is that your cancer is aggressive and needs immediate treatment such as surgery or radiation therapy. While effective at treating aggressive cancers, surgery and radiation therapy can cause long-lasting side effects, like difficulty holding urine, trouble controlling bowel movements and difficulty getting and/or keeping an erection. These problems are common after prostate cancer treatment and can make a big difference in your quality of life and relationships.

The lower your GPS, the less likely it is that your cancer is aggressive and needs immediate treatment. Through a program of regular check-ups and tests, you might delay or even avoid the life-altering side effects of immediate treatment without hurting your chance for long-term survival. These regular office visits and monitoring are known as active surveillance.

Active surveillance is a proactive treatment strategy to closely monitor and follow your cancer—if any changes are detected, you and your physician can immediately discuss alternative treatment options.

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