NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) for Breast Cancer Elevate the 21-Gene (Oncotype DX Breast Recurrence Score) Test as the Only Preferred Multigene Test to Predict Chemotherapy Benefit

Node-Negative: Chemotherapy Benefit

Updated NCCN Guidelines® from the National Comprehensive Cancer Network® (NCCN®) underscore the unique advantage of the 21-gene (Oncotype DX) test as the only preferred multi-gene test to determine chemotherapy benefit for patients with node-negative early-stage breast cancer. (See page BINV-6 in the Guidelines.)

Node-Positive: Inclusion in the Algorithm

Additionally, the NCCN Guidelines elevated multi-gene assays, including the 21-gene (Oncotype DX) test into the algorithm to consider for assessing prognosis and determining chemotherapy benefit for patients with micrometastases and 1–3 positive nodes. (See page BINV-7 in the Guidelines.)

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1. NCCN Clinical Practice Guidelines in Oncology NCCN Guidelines® V3.2018.

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