Oncotype DX Breast DCIS Score

About Oncotype DX Breast DCIS Score

Approximately 20% of all new breast cancers diagnosed in the United States are ductal carcinoma in situ (DCIS)1, but no two DCIS patients—or their tumors—are the same.

 

20% of all new breast cancer in the US are DCISApproximately 20% of all new breast cancer in the United States are DCIS1 It is estimated that by 2020, more than
one million women
in the United States will be living with a DCIS diagnosis, up from 500,000 in 20051
the first and only clinically-validated, commercially available genomic test for patients with DCIS

The Oncotype DX Breast DCIS Score test is the first clinically-validated, commercially available genomic test for patients with DCIS. It looks at the unique biology of a patient’s tumor—so you can better personalize the treatment plan for each patient’s unique situation. Find out if your patient is eligible and order the test.

An individualized assessment of risk

Generally DCIS is a non-lethal form of breast cancer, but treatments—such as surgery, radiation therapy, and hormonal therapy—can be relatively aggressive. The key to choosing the right treatment options is assessing the patient’s risk for a local recurrence (DCIS or invasive carcinoma). Often, this assessment is based only on clinical and pathologic factors or nomograms (standardized guidelines that rely on population-based estimates of average risk).

The Breast DCIS Score test provides an individualized assessment for the risk of local recurrence. Performed on a tumor sample after a biopsy or surgery, the test looks at 12 cancer-related genes in your patient’s tumor—giving you information that clinical and pathologic factors alone can’t provide. In fact, the test shows that patients with similar clinical and pathologic features do not necessarily have the same local recurrence risk.2-4

The Breast DCIS Score test results include 2-4:

  • An individualized prediction of the 10-year risk of any local recurrence (DCIS or invasive carcinoma) or an invasive local recurrence.
  • An established baseline for consideration of absolute benefit from radiation therapy (XRT).
  • Quantitative ER and PR single gene expression values.
  • A patient-friendly summary page to help explain the results to your patients

EXAMPLE
Case Study Comparison - Clinical use of the DCIS Score result
63-year-old patient 66-year-old patient
Menopausal Status: Postmenopausal
Tumor Type: DCIS
Tumor Size: 1.6 cm
ER Status (IHC): Positive
Nuclear Grade: 2
Comedo Necrosis: Absent
Margin Width: 2 mm
Menopausal Status: Postmenopausal
Tumor Type: DCIS
Tumor Size: 1.0 cm
ER Status (IHC): Positive
Nuclear Grade: 2
Comedo Necrosis: Absent
Margin Width: 2 mm
DCIS Score result:
3
DCIS Score result:
57
10% risk of any local recurrence (DCIS or invasive) 23% risk of any local recurrence (DCIS or invasive)
3% risk of an invasive local recurrence 13% risk of an invasive local recurrence
Cases submitted by Charles Leonard, MD, from Rocky Mountain Cancer Centers.

Results your patients can relate to

The Breast DCIS Score report includes the “DCIS Score result”, which is a number between 0-100.

  • Patients with a low risk estimate are likely to have a smaller absolute benefit from radiation therapy.
  • Patients with a high risk estimate are likely to have a greater absolute benefit from radiation therapy.

This numeric score makes it easy for patients to understand their level of risk. As a result, discussing treatment options with your patients is easier and more efficient, and patients feel more confident about their decisions.

Evidence it works

Two validation studies—ECOG E5194 and the Ontario DCIS Cohort—confirm that the DCIS Score result predicts the 10-year risk of local recurrence.2-4 In addition, studies show that physicians regularly change treatment recommendations based on the test results.5,6 Get more details about these studies .

REFERENCES

1. Allegra et al. J Natl Cancer Inst. 2010.
2. Solin et al. J Natl Cancer Inst. 2013.
3. Rakovitch et al. Breast Cancer Res Treat. 2015.
4. Rakovitch et al. J Natl Cancer Inst. 2017.
5. Alvarado et al. J Surg Oncol. 2015.
6. Manders et al. Ann Surg Oncol. 2016.

Available Now

The Oncotype DX Breast DCIS Score report provides a refined risk estimate of local recurrence.

Learn More

Refining
the Risk Estimate

 

Our Director of Medical Affairs explains how the addition of tumor size and patient age increases the predictive power of the Breast DCIS Score.

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